With the aim to explore in depth the relationship between migraine and neuroticism, and contribute to the understanding of this relation in order to provide a better treatment for migraine patients based on a personalized and more comprehensive approach, a scoping review was performed using PubMed, Scopus, and Web of Science. Neuroticism has been associated with various mental and physical disorders (e.g., chronic pain, depression), including migraine. ![]() Neuroticism can be conceptualized as a disposition to suffer anxiety and emotional disorders in general. ![]() Migraine is one of the most common, prevalent, and socioeconomically impactful disabling primary headache disorders. ![]() Headache is the first cause of consultation in neurology, and one of the most frequent reasons for consultation in general medicine.
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